What Should Men Know Before Starting TRT?
Before starting TRT, men should understand the benefits, potential risks, and necessary evaluations involved in hormone therapy. Dr. Manish Sahni, MD, reviews medical history, conducts hormone and blood tests, and discusses lifestyle factors to ensure safe and effective treatment. By understanding what to expect, including monitoring requirements and possible side effects, men can make informed decisions and achieve optimal results with Dr. Sahni’s guidance. For more information, contact us or request an appointment online. We are located at 1003 Division Street, Suite 4, Prescott, AZ 86301.


Table of Contents:
Does TRT increase the risk of heart problems?
Will I need TRT forever?
How do I choose a trusted healthcare provider for TRT?
How do I know if my symptoms are related to low testosterone?
Essential TRT Facts from Dr. Manish Sahni
At Centra Internal Medicine, we understand that testosterone replacement therapy (TRT) can be an important treatment option for men experiencing low testosterone levels. Our experienced providers stay updated on the latest research regarding TRT and its potential effects on cardiovascular health.
While earlier studies raised concerns about possible increased risks of heart attacks, strokes, or blood clots in men—especially those with pre-existing heart conditions—more recent and comprehensive research offers mixed results. Some studies suggest no significant increase in cardiovascular risk with TRT, and a few even indicate potential protective benefits for certain patients.
Given these mixed findings, the experienced team at Centra Internal Medicine emphasizes a personalized approach. Before starting TRT, we conduct a thorough evaluation of each patient’s overall health, including their heart disease risk factors such as high blood pressure, obesity, or high cholesterol. We follow FDA guidelines, ensuring the benefits and risks of TRT are carefully weighed for every individual.
If you are considering or currently undergoing testosterone therapy, it’s important to discuss your personal risk factors and ongoing health with your Centra Internal Medicine provider. We provide regular follow-up appointments and closely monitor your heart health, working with you to ensure your treatment is both safe and effective.
At Centra Internal Medicine, we understand that considering testosterone replacement therapy (TRT) brings up many important questions, including whether you’ll need to continue treatment indefinitely. The answer depends on your unique health situation and the underlying cause of your low testosterone.
In many cases, TRT is a long-term or even lifelong treatment—particularly if you have conditions such as primary testicular failure or chronic illnesses that permanently affect your body’s ability to produce adequate testosterone. If the underlying cause cannot be reversed, stopping TRT usually results in the return of symptoms like fatigue, reduced libido, and decreased muscle mass.
However, not all causes of low testosterone are permanent. Some cases related to factors such as obesity, certain medications, or acute illnesses may improve if the underlying issue is successfully addressed. In these situations, it may be possible to reduce or discontinue TRT under the careful supervision of your provider.
Our team will work closely with you to regularly monitor your hormone levels, symptoms, and overall health. We believe in personalized care, ensuring your therapy plan is tailored to your specific needs and circumstances. If it becomes appropriate to consider stopping TRT, we will guide you safely through the process, always prioritizing your well-being.
Ultimately, the need for lifelong TRT varies from person to person. At Centra Internal Medicine, we’re committed to ongoing follow-up and open communication to ensure you receive the best possible care at every step of your journey.
Selecting a trusted healthcare provider for testosterone replacement therapy (TRT) is a significant decision that can greatly impact your health and long-term treatment outcomes. At Centra Internal Medicine, we understand the importance of providing evidence-based, patient-centered care for men experiencing symptoms of low testosterone.
Our practice is staffed by board-certified internal medicine physicians who have specialized training and extensive experience in the management of hormonal imbalances, including testosterone deficiency. As internal medicine specialists, our providers are uniquely qualified to conduct a thorough evaluation of your overall health, investigate the underlying causes of your symptoms, and determine whether TRT is truly appropriate for you.
When you choose Centra Internal Medicine, you can trust that your care will begin with a comprehensive assessment. This includes a detailed medical history, physical examination, and appropriate laboratory testing to accurately diagnose low testosterone and rule out other potential causes. Our physicians will take the time to clearly explain the risks, benefits, and alternatives to TRT, as well as answer any questions you may have. We believe in transparent communication and shared decision-making, ensuring that you feel informed and empowered throughout the process.
Experience with testosterone therapy is critical for optimal outcomes. Our team has successfully treated numerous patients with low testosterone, and we adhere to the latest clinical guidelines to maximize safety and effectiveness. We emphasize regular follow-up appointments and periodic lab testing to monitor your progress, adjust dosages as needed, and promptly address any side effects or concerns.
At Centra Internal Medicine, your health and well-being are our highest priorities. We are committed to ethical, personalized care—never resorting to one-size-fits-all approaches or making unrealistic promises. If we identify other medical conditions that might be causing your symptoms, we will address those first before considering TRT.
If you’re experiencing changes in your energy, mood, or sexual health, it’s important to consider whether low testosterone (also known as low T or male hypogonadism) could be a factor. At Centra Internal Medicine, our team is dedicated to helping patients understand and address conditions like low testosterone, which can have a significant impact on your quality of life.
Testosterone is a key hormone in male health, influencing sexual function, mood, muscle mass, and overall vitality. When testosterone levels fall below the normal range, you may notice symptoms such as:
• Decreased sex drive
• Difficulty achieving or maintaining erections
• Reduced semen volume or testicular size
• Increased body fat or loss of muscle mass
• Decreased bone density or thinning hair
• Persistent fatigue or low energy
• Mood changes, including depression, irritability, or trouble concentrating
• Sleep disturbances or, occasionally, hot flashes
It’s important to know that these symptoms can also be caused by other health issues, such as thyroid disorders, depression, chronic stress, or other underlying medical conditions. Factors like aging, obesity, certain medications, and chronic illnesses can also affect testosterone levels.
At Centra Internal Medicine, our experienced providers take a comprehensive approach to your health. If you recognize several of these symptoms—especially if they’re ongoing and affecting your daily life—we encourage you to schedule a consultation. Our team will take the time to review your medical history, perform a physical exam, and discuss your concerns in detail. If appropriate, we’ll order blood tests (usually performed in the morning for the most accurate results), and may recommend repeat testing to confirm a diagnosis.
Self-diagnosing or attempting to treat low testosterone on your own can be risky. Our Centra Internal Medicine specialists are here to guide you safely through evaluation and, if needed, evidence-based treatment options tailored to your unique needs.
Before beginning Testosterone Replacement Therapy (TRT) at Centra Internal Medicine, it is vital to understand that hormone optimization is a long-term medical commitment, not a quick fix. Board-certified physician Dr. Manish Sahni, MD, believes that patient education is just as important as the treatment itself. He wants every man to know that TRT is a highly individualized process requiring precise, data-driven dosing and ongoing medical supervision. While therapy can profoundly improve your energy, mood, and physical vitality, it must be carefully managed to prevent side effects. Dr. Sahni ensures you are fully informed, confident, and comfortable before your personalized treatment begins.
At Centra Internal Medicine, we are committed to helping you achieve better health and well-being with compassionate care. For more information, please contact us or schedule an appointment online. We are located at 1003 Division Street Suite 4, Prescott, AZ 86301. We serve patients from Prescott AZ, Iron Springs AZ, Williamson AZ, Diamond Valley AZ, Prescott Valley AZ, and surrounding areas.
Check Out Our 5 Star Reviews


Additional Services You May Need
▸ Aesthetics
▸ Allergies
▸ Annual Physical Exams
▸ Gynecological Exams
▸ High Blood Pressure
▸ Immunizations
▸ Joint Injections
▸ Lab Services
▸ Migraines
▸ Minor Surgical Procedures
▸ Pre-op Clearance Exams
▸ Double Chin
▸ Acute Disease Management
▸ CDL Physical Exam
▸ Tirzepatide
▸ Phentermine
▸ Nutritional Coaching
▸ DOT Physicals
▸ FDA-Approved Oral Semaglutide (GLP-1)

Additional Services You May Need
▸ Aesthetics
▸ Allergies
▸ Annual Physical Exams
▸ Gynecological Exams
▸ High Blood Pressure
▸ Immunizations
▸ Joint Injections
▸ Lab Services
▸ Migraines
▸ Minor Surgical Procedures
▸ Pre-op Clearance Exams
▸ Double Chin
▸ Acute Disease Management
▸ Mole Removal
▸ Primary Care
▸ Same Day Appointments
▸ Sculpsure
▸ Sick Visits
▸ Wound Care
▸ TempSure
▸ Testosterone Replacement Therapy
▸ Telemedicine
▸ Weight Management
▸ Wellness
▸ Women’s Health
▸ Chronic Disease Management
▸ CDL Physical Exam
▸ Auto Accident Injury
▸ Tirzepatide
▸ Semaglutide
▸ Phentermine
▸ Contrave
▸ Nutritional Coaching
▸ DOT Physicals
▸ Vaccinations
▸ FDA-Approved Oral Semaglutide (GLP-1)


